NOVEMBER 2007 ISSUE

Pall Supor® UEAV Filter Capsules Offer High Flow Rates and Extended Service Life

Pall Supor® UEAV Filter Capsules

Designed specifically for the Biopharmaceutical industry’s ever increasing demands for smaller filtration installations capable of as good or better throughputs and flow rates, Pall product design engineers have developed the new Supor UEAV filter cartridges and capsules.

The Supor UEAV is an unconventional bioburden reduction filter that utilizes multiple patented filtration advances including Pall’s new Mach V technology polyethersulfone membrane and the new CapsulesPall pleating technique called Ultipleat®.
MachV's highly hydrophilic polyethersulfone membrane with its asymmetric pore structure allows the UEAV to possess superior “dirt holding capacity” for even the finest particles. This feature translates into an impressively long filtration life even with complex biological fluids.

Add to this the robust design advances of Ultipleat® cartiridge construction and the result is a filter with significantly longer service life, higher throughput yields, and lower pressure drops covering a plethora of biologic process applications. All these features translate into higher yields, increased safety, less processing time, less filter handling, less filter cartridge waste and less cost.

Quality and bio-safety is not sacrificed as all versions of the Supor UEAV are Pharmaceutical grade, serial numbered for lot tracing, 100% integrity tested prior to leaving the ISO 9001 certified factory, and accompanied by “P” Certificates confirming the pharmaceutical requirements:

  • Cleanliness per USP Particulates in injectables on Fiber-Releasing per 21 CFR 
  • Non-Pyrogenic per USP Bacterial Endotoxins (< 0.25 EU/ mL) 
  • Meets total organic carbon (TOC) and conductivity per USP Purified Water, pH per USP Sterile Purified Water 
  • Meets USP pH-shift per USP Sterile Purified Water 
  • Meets USP biological reactivity in vivo, for Class VI 121°C plastics
The Supor UEAV is an integrity testable, steam sterilizable, 0.2um particulate-grade rated filter with a Forward Flow test correlated titer reduction of 1 X 106 when challenged with aqueous suspensions of Brevundimonas diminuta (ATCC 19146). Materials of construction are limited to two: polyethersulfone and polypropylene. Effective membrane surface area is a remarkable 11.4 ft per 10” cartridge or capsule.

Please contact your local RHFS representative at 925-443-9800 for further information.

New Optical O2 sensors from METTLER-TOLEDO Ingold

Ryan Herco Flow Solutions is proud to announce the release of this exciting new technology from our colleagues at Mettler-Toledo. The InPro 6880i series is a new line of highly innovative optical sensors for the measurement of Dissolved Oxygen in cell culture, fermentation and chemical processing. Based on a chemo-optical measurement principle, the InPro 6880i sensor provides significant advantages for the BioPharm industry. Extremely quick start up and response time, combined with the excellent measurement quality of this revolutionary system, make it the ideal choice for cell culture, fermentation and other BioPharm processes.

The new InPro 6880i can be sterilized and installed in the bioreactor and fermenter as before, through sensor housings mounted on Ingold ports, but the InPro 6880i optical sensor does not need electrolyte or polarization eliminating inadvertent handling errors and production delays!

Inside the InPro 6880i a green-based LED light emanating from sensor electronics excites marker molecules immobilized in an oxygen-sensitive membrane layer. The excited molecules emit red light through a chemo-optical fluorescence process. An electronic detector determines the oxygen content based upon the characteristics of the fluorescent light produced.

This innovative technology, combined with Mettler-Toledo INGOLDs long-standing excellence in the measurement of oxygen in bioreactors, was refined to produce the most advanced measurement system for oxygen monitoring applications. The result: a new standard of excellence for enhanced performance and ease of use. The InPro 6880i produces extremely reproducible results with outstanding accuracy, leading to high measurement consistency.

In addition, the InPro 6880i contains the Mettler-Toledo’s groundbreaking ISM (Intelligent Sensor Management) technology, which helps to increase the safety and accuracy of the DO measurement through on-going real time sensor diagnostics. Sensor status information is analyzed online, providing operators with real-time warnings when sensor aging signs appear.

ISM also provides a plug-n-measure functionality with automatic uploading of sensor calibration data to the system’s transmitter.

Contact your local Ryan Herco Flow Solutions representative at 925-443-9800 for further information and to set up a demonstration of this exciting new technology.

THE RHFS PULSE is published quarterly to keep you informed on fluid flow innovations.
Life Sciences Editor
Chris Knese

cknese@rhfs.com
Life Sciences Colder Products Company single-use connections for transfer lines in biopharmaceutical applications. Call 1.800.848.1141 for more information.
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